Lifespan maturation and degeneration of human brain white matter.
Ontology highlight
ABSTRACT:
SUBMITTER: Yeatman JD
PROVIDER: S-EPMC4238904 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Lifespan maturation and degeneration of human brain white matter.
Yeatman Jason D JD Wandell Brian A BA Mezer Aviv A AA
Nature communications 20140917
Properties of human brain tissue change across the lifespan. Here we model these changes in the living human brain by combining quantitative magnetic resonance imaging (MRI) measurements of R1 (1/T1) with diffusion MRI and tractography (N=102, ages 7-85). The amount of R1 change during development differs between white-matter fascicles, but in each fascicle the rate of development and decline are mirror-symmetric; the rate of R1 development as the brain approaches maturity predicts the rate of R ...[more]
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