Ontology highlight
ABSTRACT:
SUBMITTER: Van Allen EM
PROVIDER: S-EPMC4238969 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Van Allen Eliezer M EM Mouw Kent W KW Kim Philip P Iyer Gopa G Wagle Nikhil N Al-Ahmadie Hikmat H Zhu Cong C Ostrovnaya Irina I Kryukov Gregory V GV O'Connor Kevin W KW Sfakianos John J Garcia-Grossman Ilana I Kim Jaegil J Guancial Elizabeth A EA Bambury Richard R Bahl Samira S Gupta Namrata N Farlow Deborah D Qu Angela A Signoretti Sabina S Barletta Justine A JA Reuter Victor V Boehm Jesse J Lawrence Michael M Getz Gad G Kantoff Philip P Bochner Bernard H BH Choueiri Toni K TK Bajorin Dean F DF Solit David B DB Gabriel Stacey S D'Andrea Alan A Garraway Levi A LA Rosenberg Jonathan E JE
Cancer discovery 20140805 10
<h4>Unlabelled</h4>Cisplatin-based chemotherapy is the standard of care for patients with muscle-invasive urothelial carcinoma. Pathologic downstaging to pT0/pTis after neoadjuvant cisplatin-based chemotherapy is associated with improved survival, although molecular determinants of cisplatin response are incompletely understood. We performed whole-exome sequencing on pretreatment tumor and germline DNA from 50 patients with muscle-invasive urothelial carcinoma who received neoadjuvant cisplatin- ...[more]