In vivo notch signaling blockade induces abnormal spermatogenesis in the mouse.
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ABSTRACT:
SUBMITTER: Murta D
PROVIDER: S-EPMC4239051 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
In vivo notch signaling blockade induces abnormal spermatogenesis in the mouse.
Murta Daniel D Batista Marta M Trindade Alexandre A Silva Elisabete E Henrique Domingos D Duarte António A Lopes-da-Costa Luís L
PloS one 20141120 11
In a previous study we identified active Notch signaling in key cellular events occurring at adult spermatogenesis. In this study, we evaluated the function of Notch signaling in spermatogenesis through the effects of in vivo Notch blockade. Adult CD1 male mice were either submitted to a long term DAPT (?-secretase inhibitor) or vehicle treatment. Treatment duration was designed to attain one half the time (25 days) or the time (43 days) required to accomplish a complete cycle of spermatogenesis ...[more]
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