Ontology highlight
ABSTRACT:
SUBMITTER: Ha MJ
PROVIDER: S-EPMC4239206 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Biometrics 20140520 3
Motivated by the problem of construction of gene co-expression network, we propose a statistical framework for estimating high-dimensional partial correlation matrix by a three-step approach. We first obtain a penalized estimate of a partial correlation matrix using ridge penalty. Next we select the non-zero entries of the partial correlation matrix by hypothesis testing. Finally we re-estimate the partial correlation coefficients at these non-zero entries. In the second step, the null distribut ...[more]