Ontology highlight
ABSTRACT:
SUBMITTER: Gondi V
PROVIDER: S-EPMC4239303 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Gondi Vinai V Pugh Stephanie L SL Tome Wolfgang A WA Caine Chip C Corn Ben B Kanner Andrew A Rowley Howard H Kundapur Vijayananda V DeNittis Albert A Greenspoon Jeffrey N JN Konski Andre A AA Bauman Glenn S GS Shah Sunjay S Shi Wenyin W Wendland Merideth M Kachnic Lisa L Mehta Minesh P MP
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20141027 34
<h4>Purpose</h4>Hippocampal neural stem-cell injury during whole-brain radiotherapy (WBRT) may play a role in memory decline. Intensity-modulated radiotherapy can be used to avoid conformally the hippocampal neural stem-cell compartment during WBRT (HA-WBRT). RTOG 0933 was a single-arm phase II study of HA-WBRT for brain metastases with prespecified comparison with a historical control of patients treated with WBRT without hippocampal avoidance.<h4>Patients and methods</h4>Eligible adult patient ...[more]