Ontology highlight
ABSTRACT:
SUBMITTER: Chen CY
PROVIDER: S-EPMC4239568 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Chen Cho-Yi CY Ho Andy A Huang Hsin-Yuan HY Juan Hsueh-Fen HF Huang Hsuan-Cheng HC
Scientific reports 20141121
The protein-protein interaction (PPI) network offers a conceptual framework for better understanding the functional organization of the proteome. However, the intricacy of network complexity complicates comprehensive analysis. Here, we adopted a phylogenic grouping method combined with force-directed graph simulation to decompose the human PPI network in a multi-dimensional manner. This network model enabled us to associate the network topological properties with evolutionary and biological impl ...[more]