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A PTCH1 homolog transcriptionally activated by p53 suppresses Hedgehog signaling.

ABSTRACT: The p53-mediated responses to DNA damage and the Hedgehog (Hh) signaling pathway are each recurrently dysregulated in many types of human cancer. Here we describe PTCH53, a p53 target gene that is homologous to the tumor suppressor gene PTCH1 and can function as a repressor of Hh pathway activation. PTCH53 (previously designated PTCHD4) was highly responsive to p53 in vitro and was among a small number of genes that were consistently expressed at reduced levels in diverse TP53 mutant cell lines and human tumors. Increased expression of PTCH53 inhibited canonical Hh signaling by the G protein-coupled receptor SMO. PTCH53 thus delineates a novel, inducible pathway by which p53 can repress tumorigenic Hh signals.

SUBMITTER: Chung JH

PROVIDER: S-EPMC4239647 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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A PTCH1 homolog transcriptionally activated by p53 suppresses Hedgehog signaling.

Chung Jon H JH Larsen Andrew R AR Chen Evan E Bunz Fred F

The Journal of biological chemistry 20141008 47

The p53-mediated responses to DNA damage and the Hedgehog (Hh) signaling pathway are each recurrently dysregulated in many types of human cancer. Here we describe PTCH53, a p53 target gene that is homologous to the tumor suppressor gene PTCH1 and can function as a repressor of Hh pathway activation. PTCH53 (previously designated PTCHD4) was highly responsive to p53 in vitro and was among a small number of genes that were consistently expressed at reduced levels in diverse TP53 mutant cell lines ...[more]

PMID: 25296753

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