Ontology highlight
ABSTRACT:
SUBMITTER: Teske K
PROVIDER: S-EPMC4240308 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Teske Kelly K Nandhikonda Premchendar P Bogart Jonathan W JW Feleke Belaynesh B Sidhu Preetpal P Yuan Nina N Preston Joshua J Goy Robin R Han Lanlan L Silvaggi Nicholas R NR Singh Rakesh K RK Bikle Daniel D DD Cook James M JM Arnold Leggy A LA
Nuclear receptor research 20140101
Herein, we described the development of two virtual screens to identify new vitamin D receptor (VDR) antagonists among nuclear receptor (NR) ligands. Therefore, a database of 14330 nuclear receptor ligands and their NR affinities was assembled using the online available "Binding Database". Two different virtual screens were carried out in conjunction with a reported VDR crystal structure applying a stringent and less stringent pharmacophore model to filter docked NR ligand conformations. The pha ...[more]