Ontology highlight
ABSTRACT:
SUBMITTER: Giedt RJ
PROVIDER: S-EPMC4240345 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Bioconjugate chemistry 20141103 11
Overexpression of anti-apoptotic proteins such as Bcl-2 is a cellular mechanism to evade apoptosis; consequently, Bcl-2 inhibitors are being developed as anticancer agents. In this work, we have synthesized a fluorescent version of ABT-199 in an effort to visualize a drug surrogate by high resolution imaging. We show that this fluorescent conjugate has comparable Bcl-2 binding efficacy and cell line potency to the parent compound and can be used as an imaging agent in several cancer cell types. ...[more]