Plasma proteins predict conversion to dementia from prodromal disease.
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ABSTRACT: Background
The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia.Methods
Three multicenter cohorts of cognitively healthy elderly, mild cognitive impairment (MCI), and AD participants with standardized clinical assessments and structural neuroimaging measures were used. Twenty-six candidate proteins were quantified in 1148 subjects using multiplex (xMAP) assays.Results
Sixteen proteins correlated with disease severity and cognitive decline. Strongest associations were in the MCI group with a panel of 10 proteins predicting progression to AD (accuracy 87%, sensitivity 85%, and specificity 88%).Conclusions
We have identified 10 plasma proteins strongly associated with disease severity and disease progression. Such markers may be useful for patient selection for clinical trials and assessment of patients with predisease subjective memory complaints.
SUBMITTER: Hye A
PROVIDER: S-EPMC4240530 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Plasma proteins predict conversion to dementia from prodromal disease.
Hye Abdul A Riddoch-Contreras Joanna J Baird Alison L AL Ashton Nicholas J NJ Ashton Nicholas J NJ Bazenet Chantal C Leung Rufina R Westman Eric E Simmons Andrew A Dobson Richard R Sattlecker Martina M Lupton Michelle M Lunnon Katie K Keohane Aoife A Ward Malcolm M Pike Ian I Zucht Hans Dieter HD Pepin Danielle D Zheng Wei W Tunnicliffe Alan A Richardson Jill J Gauthier Serge S Soininen Hilkka H Kłoszewska Iwona I Mecocci Patrizia P Tsolaki Magda M Vellas Bruno B Lovestone Simon S
Alzheimer's & dementia : the journal of the Alzheimer's Association 20140708 6
<h4>Background</h4>The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia.<h4>Methods</h4>Three multicenter cohorts of cognitively healthy elderly, mild cognitive impairment (MCI), and AD participants with standardized clinical assessments and structural neuroimaging measures were used. Twenty-six candidate proteins wer ...[more]
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