The levels of MDA-LDL in circulating immune complexes predict myocardial infarction in the VADT study.

ABSTRACT:

Objective

Circulating immune complexes (IC) containing modified forms of LDL (mLDL) are strongly pro-inflammatory and strong predictors of cardiovascular disease (CVD) progression in type 1 diabetes. The present study was undertaken to determine whether the levels of oxidized LDL (oxLDL), malondialdehyde-LDL (MDA-LDL) and advanced glycation end products-LDL (AGE-LDL) in IC predict incident CVD events in type 2 diabetes (VADT cohort).

Methods and results

Levels of mLDL in IC were measured in 907 patients of the VADT cohort, a median of two years after entry into the study. Participants were followed for an average of 3.7 years for vascular outcomes. Hazard ratios (HRs) for CV endpoints in relation to mLDL-IC quartiles were calculated by Cox proportional hazard models. The pri

SUBMITTER: Lopes-Virella MF 

PROVIDER: S-EPMC4240617 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature