Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach.

ABSTRACT:

Background

An unbiased systems approach was used to define energy metabolic events that occur during the pathological cardiac remodeling en route to heart failure (HF).

Methods and results

Combined myocardial transcriptomic and metabolomic profiling were conducted in a well-defined mouse model of HF that allows comparative assessment of compensated and decompensated (HF) forms of cardiac hypertrophy because of pressure overload. The pressure overload data sets were also compared with the myocardial transcriptome and metabolome for an adaptive (physiological) form of cardiac hypertrophy because of endurance exercise training. Comparative analysis of the data sets led to the following conclusions: (1) expression of most genes involved in mitochondrial energy transduction were

SUBMITTER: Lai L 

PROVIDER: S-EPMC4241130 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature