Ontology highlight
ABSTRACT:
SUBMITTER: Grieder TE
PROVIDER: S-EPMC4241147 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Grieder Taryn E TE Herman Melissa A MA Contet Candice C Tan Laura A LA Vargas-Perez Hector H Cohen Ami A Chwalek Michal M Maal-Bared Geith G Freiling John J Schlosburg Joel E JE Clarke Laura L Crawford Elena E Koebel Pascale P Repunte-Canonigo Vez V Sanna Pietro P PP Tapper Andrew R AR Roberto Marisa M Kieffer Brigitte L BL Sawchenko Paul E PE Koob George F GF van der Kooy Derek D George Olivier O
Nature neuroscience 20141117 12
Dopaminergic neurons in the ventral tegmental area (VTA) are well known for mediating the positive reinforcing effects of drugs of abuse. Here we identify in rodents and humans a population of VTA dopaminergic neurons expressing corticotropin-releasing factor (CRF). We provide further evidence in rodents that chronic nicotine exposure upregulates Crh mRNA (encoding CRF) in dopaminergic neurons of the posterior VTA, activates local CRF1 receptors and blocks nicotine-induced activation of transien ...[more]