Heterogeneous red blood cell adhesion and deformability in sickle cell disease.
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ABSTRACT:
SUBMITTER: Alapan Y
PROVIDER: S-EPMC4241514 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Heterogeneous red blood cell adhesion and deformability in sickle cell disease.
Alapan Yunus Y Little Jane A JA Gurkan Umut A UA
Scientific reports 20141124
We present a microfluidic approach that allows simultaneous interrogation of RBC properties in physiological flow conditions at a single cell level. With this method, we studied healthy hemoglobin A (HbA) and homozygous sickle hemoglobin (HbS) containing RBCs using whole blood samples from twelve subjects. We report that HbS-containing RBCs are heterogeneous in terms of adhesion and deformability in flow. ...[more]
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