Ontology highlight
ABSTRACT:
SUBMITTER: Calantone N
PROVIDER: S-EPMC4241569 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Calantone Nina N Wu Fan F Klase Zachary Z Deleage Claire C Perkins Molly M Matsuda Kenta K Thompson Elizabeth A EA Ortiz Alexandra M AM Vinton Carol L CL Ourmanov Ilnour I Loré Karin K Douek Daniel C DC Estes Jacob D JD Hirsch Vanessa M VM Brenchley Jason M JM
Immunity 20140901 3
The viral accessory protein Vpx, expressed by certain simian and human immunodeficiency viruses (SIVs and HIVs), is thought to improve viral infectivity of myeloid cells. We infected 35 Asian macaques and African green monkeys with viruses that do or do not express Vpx and examined viral targeting of cells in vivo. While lack of Vpx expression affected viral dynamics in vivo, with decreased viral loads and infection of CD4⁺ T cells, Vpx expression had no detectable effect on infectivity of myelo ...[more]