Ontology highlight
ABSTRACT:
SUBMITTER: Dings RP
PROVIDER: S-EPMC4242102 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Dings Ruud P M RP Levine Joseph I JI Brown Susan G SG Astorgues-Xerri Lucile L MacDonald John R JR Hoye Thomas R TR Raymond Eric E Mayo Kevin H KH
Investigational new drugs 20130208 5
Previously, we reported on the anti-tumor activities of two designed calix[4]arene-based topomimetics (PTX008 and PTX009) of the amphipathic, angiostatic peptide Anginex. Here, we chemically modified the hydrophobic and hydrophilic faces of PTX008 and PTX009, and discovered new calixarene compounds that are more potent, cytotoxic anti-tumor agents. One of them, PTX013, is particularly effective at inhibiting the growth of several human cancer cell lines, as well as drug resistant cancer cells. M ...[more]