Ontology highlight
ABSTRACT:
SUBMITTER: Alexaki A
PROVIDER: S-EPMC4242445 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Alexaki Aikaterini A Gupta Sita D SD Majumder Saurav S Kono Mari M Tuymetova Galina G Harmon Jeffrey M JM Dunn Teresa M TM Proia Richard L RL
Journal of lipid research 20141020 12
Sphingolipid levels are tightly regulated to maintain cellular homeostasis. During pathologic conditions such as in aging, inflammation, and metabolic and neurodegenerative diseases, levels of some sphingolipids, including the bioactive metabolite ceramide, are elevated. Sphingolipid metabolism has been linked to autophagy, a critical catabolic process in both normal cell function and disease; however, the in vivo relevance of the interaction is not well-understood. Here, we show that blocking a ...[more]