Dataset Information

Elevated levels of plasma D-dimer predict a worse outcome in patients with nasopharyngeal carcinoma.

ABSTRACT:

Background

Hemostatic alterations occur during the development of cancer. Plasma D-dimer is a hypercoagulability and fibrinolytic system marker that is increased in patients with various solid tumours. The aim of this study was to evaluate the hemostatic status of nasopharyngeal carcinoma (NPC) patients by assessing plasma D-dimer levels to investigate its value as a prognostic marker.

Methods

We retrospectively analysed 717 patients with nasopharyngeal carcinoma, and we applied Cox regression and log-rank tests to assess the association of D-dimer levels with disease-free survival (DFS), distant metastasis-free survival (DMFS), and overall survival (OS). D-dimer levels were measured using a quantitative D-dimer latex agglutination assay.

Results

Using the 3rd quartile values (0.8 ?g/L) as the optimal cut-offs, we found that patients with high D-dimer levels have a shorter 3-year DFS, (79%, 95%CI (73.1-84.9)) vs. (69%, 95%CI (59.2-78.8)), DMFS (87%, 95%CI (83.1-90.9)) vs. (77%, 95%CI (69.2-84.8)), and overall survival (82%, 95%CI (76.1-87.9)) vs. (76%, 95%CI (66.2-85.8)). Multivariate analysis revealed that pre-treatment D-dimer levels and EBV DNA were significant independent factors for DFS, DMFS, and OS in NPC patients. Subgroup analyses indicated that the plasma D-dimer levels could effectively stratify patient prognosis for early cancer, advanced stage cancer, and patients with EBV DNA ?4000 copies/ml.

Conclusions

High D-dimer levels were associated with poor disease-free survival, distant metastasis-free survival, overall survival, and increased risk of mortality in NPC patients. Prospective trials are required to assess the prognostic value of D-dimer levels.

SUBMITTER: Chen WH

PROVIDER: S-EPMC4242497 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Publications

Elevated levels of plasma D-dimer predict a worse outcome in patients with nasopharyngeal carcinoma.

Chen Wen-Hui WH Tang Lin-Quan LQ Wang Feng-Wei FW Li Chang-Peng CP Tian Xiao-Peng XP Huang Xiao-Xia XX Mai Shi-Juan SJ Liao Yi-Ji YJ Deng Hai-Xia HX Chen Qiu-Yan QY Liu Huai H Zhang Lu L Guo Shan-Shan SS Liu Li-Ting LT Yan Shu-Mei SM Li Chao-Feng CF Zhang Jing-Ping JP Liu Qing Q Liu Xue-Wen XW Liu Li-Zhi LZ Mai Hai-Qiang HQ Zeng Mu-Sheng MS Xie Dan D

BMC cancer 20140810

<h4>Background</h4>Hemostatic alterations occur during the development of cancer. Plasma D-dimer is a hypercoagulability and fibrinolytic system marker that is increased in patients with various solid tumours. The aim of this study was to evaluate the hemostatic status of nasopharyngeal carcinoma (NPC) patients by assessing plasma D-dimer levels to investigate its value as a prognostic marker.<h4>Methods</h4>We retrospectively analysed 717 patients with nasopharyngeal carcinoma, and we applied C ...[more]

PMID: 25109220

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Dataset Information

Elevated levels of plasma D-dimer predict a worse outcome in patients with nasopharyngeal carcinoma.

Background

Methods

Results

Conclusions

Publications

Elevated levels of plasma D-dimer predict a worse outcome in patients with nasopharyngeal carcinoma.

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