Causal directed acyclic graphs and the direction of unmeasured confounding bias.

ABSTRACT: We present results that allow the researcher in certain cases to determine the direction of the bias that arises when control for confounding is inadequate. The results are given within the context of the directed acyclic graph causal framework and are stated in terms of signed edges. Rigorous definitions for signed edges are provided. We describe cases in which intuition concerning signed edges fails and we characterize the directed acyclic graphs that researchers can use to draw conclusions about the sign of the bias of unmeasured confounding. If there is only one unmeasured confounding variable on the graph, then nonincreasing or nondecreasing average causal effects suffice to draw conclusions about the direction of the bias. When there are more than one unmeasured confounding variable,

SUBMITTER: VanderWeele TJ 

PROVIDER: S-EPMC4242711 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature