Ontology highlight
ABSTRACT:
SUBMITTER: MacLean DM
PROVIDER: S-EPMC4242809 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
MacLean David M DM Ramaswamy Swarna S SS Du Mei M Howe James R JR Jayaraman Vasanthi V
The Journal of general physiology 20141201 6
Transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs) markedly enhance AMPAR function, altering ligand efficacy and receptor gating kinetics and thereby shaping the postsynaptic response. The structural mechanism underlying TARP effects on gating, however, is unknown. Here we find that the prototypical member of the TARP family, stargazin or γ-2, rescues gating deficits in AMPARs carrying mutations that destabilize the closed-cleft states of the ligand-binding domain (LBD), suggesting ...[more]