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Polymorphism of the IL-18 and CD40 genes and Liver Transplant Outcome in Iranian Patients.

ABSTRACT: BACKGROUND:Cytokines and co-stimulatory molecules are important factors determining the outcome of transplantation. OBJECTIVE:To investigate the effect of IL-18 and CD40 gene polymorphisms on the outcome of liver transplantation. METHODS:150 liver transplant recipients were included in this study. Alleles and genotypes frequencies for IL-18 (rs1946519) and CD40 (rs1883832) were determined in 28 acutely rejected (AR group) and 122 non-acutely rejected (non-AR group) liver transplant recipients. IL-18 and CD40 gene polymorphisms were evaluated by PCR-RFLP methods. RESULTS:There were no significant associations between IL-18 and CD40 polymorphism with acute rejection in liver transplant patients. IL-18TT and TG genotypes had a significant association with rejection in women compared to men. After grouping the liver recipients according to living vs cadaver donors, a significant association was found between CC genotype of CD40 and rejection in male living donor recipients. IL-18 TG genotype had a significant association with rejection in female cadaver donor recipients. CONCLUSION:There is no correlation between all genotype and alleles of IL-80 and CD40 polymorphism and the outcome of liver transplantation. However, gender and type of donor affect the correlation between all genotype and alleles of IL-18 and CD40, and the outcome of liver transplantation.

SUBMITTER: Hejr S

PROVIDER: S-EPMC4243046 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Polymorphism of the IL-18 and CD40 genes and Liver Transplant Outcome in Iranian Patients.

Hejr S S Karimi M H MH Sabet S S Mohammadi B B Nikeghbalian S S Geramizadeh B B Yaghobi R R

International journal of organ transplantation medicine 20140101 4

<h4>Background</h4>Cytokines and co-stimulatory molecules are important factors determining the outcome of transplantation.<h4>Objective</h4>To investigate the effect of IL-18 and CD40 gene polymorphisms on the outcome of liver transplantation.<h4>Methods</h4>150 liver transplant recipients were included in this study. Alleles and genotypes frequencies for IL-18 (rs1946519) and CD40 (rs1883832) were determined in 28 acutely rejected (AR group) and 122 non-acutely rejected (non-AR group) liver tr ...[more]

PMID: 25426283

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Project description:IntroductionThe present study aimed to determine the alterations in the serum levels of tumor markers used to evaluate cardiac, renal and liver function, and detect the interleukin (IL)-18 rs1946518 polymorphism in breast (BC), colorectal (CRC) and prostate cancer (PCa) patients.MethodsBlood samples were collected from 65 female BC, 116 CRC, 79 PCa and 88 myocardial infarction (MI) patients, and 110 healthy individuals to determine the concentration of tumor and cardiac markers. Furthermore, the IL-18 rs1946518 polymorphism was assessed using amplification refractory mutation system (ARMS)-PCR.ResultsThe serum levels of the tumor markers cancer antigen 15-3 (CA 15-3), carbohydrate antigen 19-9 (CA 19-9), carcinoembryonic antigen (CEA) and total prostate-specific antigen (TPSA) were significantly increased in cancer patients compared with healthy controls. Furthermore, the activity of high-sensitivity cardiac troponin T (hs-cTnT) and creatine kinase‑myocardial band (CK-MB) was enhanced in MI patients, however, their activity was unchanged in cancer patients. The activity of alkaline phosphatase (ALP), and the serum concentration of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and urea were markedly elevated in CRC and PCa patients, respectively, compared with the control group. Although, no significant differences were observed in the -607 C/A polymorphism and allele frequency of IL-18 among BC, CRC patients and healthy individuals, the odds ratio (OR) was 1.75 for both C and A allele in BC patients. Therefore, the -607 C/A polymorphism could be considered as a risk factor for BC.ConclusionThe aforementioned results suggested that tumor markers could be considered as excellent biomarkers for the early detection of BC, CRC and PCa, whereas the concentration of liver enzymes could serve as an alternative indicator for the diagnosis of CRC and PCa. Additionally, the rs1946518 polymorphism in the IL-18 gene could be considered as a risk factor for the occurrence of BC, CRC and PCa..

Dataset Information

Polymorphism of the IL-18 and CD40 genes and Liver Transplant Outcome in Iranian Patients.

Publications

Polymorphism of the IL-18 and CD40 genes and Liver Transplant Outcome in Iranian Patients.

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