MirMark: a site-level and UTR-level classifier for miRNA target prediction.
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ABSTRACT:
SUBMITTER: Menor M
PROVIDER: S-EPMC4243195 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
mirMark: a site-level and UTR-level classifier for miRNA target prediction.
Menor Mark M Ching Travers T Zhu Xun X Garmire David D Garmire Lana X LX
Genome biology 20140101 10
MiRNAs play important roles in many diseases including cancers. However computational prediction of miRNA target genes is challenging and the accuracies of existing methods remain poor. We report mirMark, a new machine learning-based method of miRNA target prediction at the site and UTR levels. This method uses experimentally verified miRNA targets from miRecords and mirTarBase as training sets and considers over 700 features. By combining Correlation-based Feature Selection with a variety of st ...[more]
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