Ontology highlight
ABSTRACT:
SUBMITTER: Pathania S
PROVIDER: S-EPMC4243249 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Pathania Shailja S Bade Sangeeta S Le Guillou Morwenna M Burke Karly K Reed Rachel R Bowman-Colin Christian C Su Ying Y Ting David T DT Polyak Kornelia K Richardson Andrea L AL Feunteun Jean J Garber Judy E JE Livingston David M DM
Nature communications 20141117
BRCA1-a breast and ovarian cancer suppressor gene-promotes genome integrity. To study the functionality of BRCA1 in the heterozygous state, we established a collection of primary human BRCA1(+/+) and BRCA1(mut/+) mammary epithelial cells and fibroblasts. Here we report that all BRCA1(mut/+) cells exhibited multiple normal BRCA1 functions, including the support of homologous recombination- type double-strand break repair (HR-DSBR), checkpoint functions, centrosome number control, spindle pole for ...[more]