Ontology highlight
ABSTRACT:
SUBMITTER: Evans ML
PROVIDER: S-EPMC4243835 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Evans Margery L ML Chapman Matthew R MR
Biochimica et biophysica acta 20130927 8
Many bacteria assemble extracellular amyloid fibers on their cell surface. Secretion of proteins across membranes and the assembly of complex macromolecular structures must be highly coordinated to avoid the accumulation of potentially toxic intracellular protein aggregates. Extracellular amyloid fiber assembly poses an even greater threat to cellular health due to the highly aggregative nature of amyloids and the inherent toxicity of amyloid assembly intermediates. Therefore, temporal and spati ...[more]