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A proposal for dose-adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time.


ABSTRACT: Dabigatran is an oral anticoagulant that is increasingly used for atrial fibrillation (AF). Presently, many authorities state that routine laboratory coagulation monitoring is not required. However, data have recently been published demonstrating that higher trough plasma dabigatran concentrations are associated with lower thromboembolic and higher haemorrhagic event rates. Using these data, we simulate a range of AF patients with varying risks for these events and derive a target range of trough plasma dabigatran concentrations (30-130??g?l(-1) ). Finally, we propose that a conventional screening coagulation assay, the thrombin time (TT), can be used to discern whether or not patients are within this range of dabigatran concentrations.

SUBMITTER: Chin PK 

PROVIDER: S-EPMC4243910 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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A proposal for dose-adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time.

Chin Paul K L PK   Wright Daniel F B DF   Patterson David M DM   Doogue Matthew P MP   Begg Evan J EJ  

British journal of clinical pharmacology 20140901 3


Dabigatran is an oral anticoagulant that is increasingly used for atrial fibrillation (AF). Presently, many authorities state that routine laboratory coagulation monitoring is not required. However, data have recently been published demonstrating that higher trough plasma dabigatran concentrations are associated with lower thromboembolic and higher haemorrhagic event rates. Using these data, we simulate a range of AF patients with varying risks for these events and derive a target range of troug  ...[more]

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