Ontology highlight
ABSTRACT:
SUBMITTER: Weiser PT
PROVIDER: S-EPMC4243926 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20131108 2
A series of unsymmetrically substituted biphenyl compounds was designed as alpha helical proteomimetics with the aim of inhibiting the binding of coactivator proteins to the nuclear hormone receptor coactivator binding domain. These compounds were synthesized in good overall yields in seven steps starting from 2-bromoanisole. The final products were evaluated using cotransfection reporter gene assays and mammalian two-hybrid competitive inhibition assays to demonstrate their effectiveness as com ...[more]