Influence of hydroxyapatite-coated and growth factor-releasing interference screws on tendon-bone healing in an ovine model.

ABSTRACT:

Purpose

Our purpose was to determine whether a bioresorbable interference screw coated with a hydroxyapatite-based mineral layer designed to release an engineered peptide growth factor (linkBMP-2 [where "BMP-2" indicates bone morphogenetic protein 2]) improved tendon-bone healing compared with a screw without coating.

Methods

Tagged linkBMP-2 peptides were used to quantify binding efficiency and release kinetics on 9 mineral-coated BIORCI screws (Smith & Nephew, Andover, MA). Fourteen mature female sheep were used in this study. In each of the 14 sheep, each stifle was randomized to either receive a linkBMP-2-coated or uncoated interference screw (n = 14 per treatment). The sheep were euthanized at 6 weeks after surgery. Eight sheep were subjected to biomechanical testing fo

SUBMITTER: Lu Y 

PROVIDER: S-EPMC4243967 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature