Interatrial pressure gradients during simulated obstructive sleep apnea: a catheter-based study.

ABSTRACT: We set to measure the interatrial pressure gradient during simulated obstructive sleep apnea (OSA).OSA occurs when a sleeping patient attempts to inhale against an obstructed airway. How this event affects the interatrial pressure gradient has not been defined. We hypothesized that simulated OSA in a conscious subject (Mueller maneuver [MM], inspiration against obstruction) would promote increased right-to-left pressure gradient, and then the substrate for right-to-left atrial shunting.Selected patients underwent simultaneous measurement of airway and atrial pressures (both left and right atrium [LA, RA]) using high-fidelity micromanometry at rest, during MM, and during VM, during right heart catheterization.Ten patients (age 55?±?11 years, two women) were successfully studied. During the onset of MM, RA pressure transiently but consistently exceeded LA pressure in response to the steep decline in intrathoracic pressure (maximum RA-LA pressure gradient increased from 0.1?±?1.4 mm Hg at baseline to 7.0?±?4.3 mm Hg during MM, P?

SUBMITTER: Konecny T 

PROVIDER: S-EPMC4244266 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature