Dataset Information

Hospitalisation for chronic obstructive pulmonary disease and risk of suicide: a population-based case-control study.

ABSTRACT:

Objectives

To examine risk of suicide among individuals with hospitalised chronic obstructive pulmonary disease (COPD) and to profile differences according to sex, age, psychiatric history, and recency and frequency of COPD hospitalisations.

Design

Nested case-control study.

Setting

Data were retrieved from Danish national registries.

Participants

All suicide cases aged 40-95 years deceased between 1981 and 2006 in Denmark (n=19,869) and up to 20 live population controls per case matched on sex and date of birth (n=321,867 controls).

Main outcome measures

The relative risk of suicide associated with COPD was computed using conditional logistic regression and adjusted for effects of psychiatric history and important sociodemographic factors.

Results

In our study population, 3% of suicide cases had been hospitalised for COPD compared with 1% of matched population controls. Thus, a hospitalised COPD was associated with a significantly increased risk for suicide (OR 2.6; 95% CI 2.3 to 2.8). The increased risk remained significant after adjustment for psychiatric history and sociodemographic variables (OR 2.0; 95% CI 1.8 to 2.2), and increased progressively with frequency and recency of COPD hospitalisation. At the same time, suicide risk associated with COPD differed significantly by sex, age and psychiatric status. The relative risk was more pronounced in women, in individuals older than 60 years and in persons with no history of psychiatric illness.

Conclusions

COPD confers an important risk factor for suicide completion. Risk assessment and prevention efforts should take patients' sex, age and psychiatric history into consideration.

SUBMITTER: Strid JM

PROVIDER: S-EPMC4244413 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Publications

Hospitalisation for chronic obstructive pulmonary disease and risk of suicide: a population-based case-control study.

Strid Jennie Maria Christin JM Christiansen Christian Fynbo CF Olsen Morten M Qin Ping P

BMJ open 20141124 11

<h4>Objectives</h4>To examine risk of suicide among individuals with hospitalised chronic obstructive pulmonary disease (COPD) and to profile differences according to sex, age, psychiatric history, and recency and frequency of COPD hospitalisations.<h4>Design</h4>Nested case-control study.<h4>Setting</h4>Data were retrieved from Danish national registries.<h4>Participants</h4>All suicide cases aged 40-95 years deceased between 1981 and 2006 in Denmark (n=19,869) and up to 20 live population cont ...[more]

PMID: 25421339

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Project description:BackgroundGenetic factors influence chronic obstructive pulmonary disease (COPD) risk, but the individual variants that have been identified have small effects. We hypothesised that a polygenic risk score using additional variants would predict COPD and associated phenotypes.MethodsWe constructed a polygenic risk score using a genome-wide association study of lung function (FEV1 and FEV1/forced vital capacity [FVC]) from the UK Biobank and SpiroMeta. We tested this polygenic risk score in nine cohorts of multiple ethnicities for an association with moderate-to-severe COPD (defined as FEV1/FVC <0·7 and FEV1 <80% of predicted). Associations were tested using logistic regression models, adjusting for age, sex, height, smoking pack-years, and principal components of genetic ancestry. We assessed predictive performance of models by area under the curve. In a subset of studies, we also studied quantitative and qualitative CT imaging phenotypes that reflect parenchymal and airway pathology, and patterns of reduced lung growth.FindingsThe polygenic risk score was associated with COPD in European (odds ratio [OR] per SD 1·81 [95% CI 1·74-1·88] and non-European (1·42 [1·34-1·51]) populations. Compared with the first decile, the tenth decile of the polygenic risk score was associated with COPD, with an OR of 7·99 (6·56-9·72) in European ancestry and 4·83 (3·45-6·77) in non-European ancestry cohorts. The polygenic risk score was superior to previously described genetic risk scores and, when combined with clinical risk factors (ie, age, sex, and smoking pack-years), showed improved prediction for COPD compared with a model comprising clinical risk factors alone (AUC 0·80 [0·79-0·81] vs 0·76 [0·75-0·76]). The polygenic risk score was associated with CT imaging phenotypes, including wall area percent, quantitative and qualitative measures of emphysema, local histogram emphysema patterns, and destructive emphysema subtypes. The polygenic risk score was associated with a reduced lung growth pattern.InterpretationA risk score comprised of genetic variants can identify a small subset of individuals at markedly increased risk for moderate-to-severe COPD, emphysema subtypes associated with cigarette smoking, and patterns of reduced lung growth.FundingUS National Institutes of Health, Wellcome Trust.

Dataset Information

Hospitalisation for chronic obstructive pulmonary disease and risk of suicide: a population-based case-control study.

Objectives

Design

Setting

Participants

Main outcome measures

Results

Conclusions

Publications

Hospitalisation for chronic obstructive pulmonary disease and risk of suicide: a population-based case-control study.

Similar Datasets

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