Dataset Information

Classification of osteoarthritis phenotypes by metabolomics analysis.

ABSTRACT:

Objectives

To identify metabolic markers that can classify patients with osteoarthritis (OA) into subgroups.

Design

A case-only study design was utilised.

Participants

Patients were recruited from those who underwent total knee or hip replacement surgery due to primary OA between November 2011 and December 2013 in St. Clare's Mercy Hospital and Health Science Centre General Hospital in St. John's, capital of Newfoundland and Labrador (NL), Canada. 38 men and 42 women were included in the study. The mean age was 65.2±8.7?years.

Outcome measures

Synovial fluid samples were collected at the time of their joint surgeries. Metabolic profiling was performed on the synovial fluid samples by the targeted metabolomics approach, and various analytic methods were utilised to identify metabolic markers for classifying subgroups of patients with OA. Potential confounders such as age, sex, body mass index (BMI) and comorbidities were considered in the analysis.

Results

Two distinct patient groups, A and B, were clearly identified in the 80 patients with OA. Patients in group A had a significantly higher concentration on 37 of 39 acylcarnitines, but the free carnitine was significantly lower in their synovial fluids than in those of patients in group B. The latter group was further subdivided into two subgroups, that is, B1 and B2. The corresponding metabolites that contributed to the grouping were 86 metabolites including 75 glycerophospholipids (6 lysophosphatidylcholines, 69 phosphatidylcholines), 9 sphingolipids, 1 biogenic amine and 1 acylcarnitine. The grouping was not associated with any known confounders including age, sex, BMI and comorbidities. The possible biological processes involved in these clusters are carnitine, lipid and collagen metabolism, respectively.

Conclusions

The study demonstrated that OA consists of metabolically distinct subgroups. Identification of these distinct subgroups will help to unravel the pathogenesis and develop targeted therapies for OA.

SUBMITTER: Zhang W

PROVIDER: S-EPMC4244434 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Publications

Classification of osteoarthritis phenotypes by metabolomics analysis.

Zhang Weidong W Likhodii Sergei S Zhang Yuhua Y Aref-Eshghi Erfan E Harper Patricia E PE Randell Edward E Green Roger R Martin Glynn G Furey Andrew A Sun Guang G Rahman Proton P Zhai Guangju G

BMJ open 20141119 11

<h4>Objectives</h4>To identify metabolic markers that can classify patients with osteoarthritis (OA) into subgroups.<h4>Design</h4>A case-only study design was utilised.<h4>Participants</h4>Patients were recruited from those who underwent total knee or hip replacement surgery due to primary OA between November 2011 and December 2013 in St. Clare's Mercy Hospital and Health Science Centre General Hospital in St. John's, capital of Newfoundland and Labrador (NL), Canada. 38 men and 42 women were i ...[more]

PMID: 25410606

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Dataset Information

Classification of osteoarthritis phenotypes by metabolomics analysis.

Objectives

Design

Participants

Outcome measures

Results

Conclusions

Publications

Classification of osteoarthritis phenotypes by metabolomics analysis.

Similar Datasets

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