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Recognition and reporting of suspected adverse drug reactions by surveyed healthcare professionals in Uganda: key determinants.


ABSTRACT:

Objective

To assess extent and determinants of past-month recognition of suspected adverse drug reactions (ADR) and past-year ADR reporting among healthcare professionals (HCPs) in Uganda.

Setting

Geographically diverse health facilities (public, private for-profit, private not-for-profit).

Participants

Of 2000 questionnaires distributed, 1345 were completed: return rate of 67%.

Primary and secondary outcome measures

Per cent HCPs who suspected ADR in the past month; reported ADR in the past year.

Results

Nurses were the majority (59%, 792/1345). Only half the respondents had heard about pharmacovigilance: 39% of nurses (295/763; 95% CI 35% to 42%), 70% otherwise (383/547; 95% CI 66% to 74%). One fifth (268/1289 or 21%; 95% CI 19% to 23%) had suspected an ADR in the previous 4 weeks, 111 of them were nurses; 15% (190/1296) had reported a suspected ADR in the past year, 103 of them were nurses. Past-month ADR suspicion was more likely by non-nurses (OR=1.7, 95% CI 1.16 to 2.40) and with medical research involvement (OR=1.5, 95% CI 1.05 to 2.15) but past-month receipt of patient ADR-complaint predominated (OR=19, 95% CI 14 to 28). Past-year ADR reporting was higher by hospital staff (OR=1.9, 95% CI 1.18 to 3.10), especially in medicine (OR=2.3, 95% CI 1.08 to 4.73); but lower from private for-profit health facilities (OR=0.5, 95% CI 0.28 to 0.77) and by older staff (OR=0.6, 95% CI 0.43 to 0.91); more likely by HCPs who had ever encountered a fatal ADR (OR=2.9, 95% CI 1.94 to 4.25), knew to whom to report (OR=1.7, 95% CI 1.18 to 2.46), or suggested how to improve ADR reporting (OR=1.6, 95% CI 1.04 to 2.49). Two attitudinal factors were important: diffidence and lethargy.

Conclusions

One in five HCPs suspected an ADR in the past-month and one in seven reported ADR in the previous year. Empowering patients could strengthen ADR detection and reporting in Africa.

SUBMITTER: Kiguba R 

PROVIDER: S-EPMC4244492 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Publications

Recognition and reporting of suspected adverse drug reactions by surveyed healthcare professionals in Uganda: key determinants.

Kiguba Ronald R   Karamagi Charles C   Waako Paul P   Ndagije Helen B HB   Bird Sheila M SM  

BMJ open 20141124 11


<h4>Objective</h4>To assess extent and determinants of past-month recognition of suspected adverse drug reactions (ADR) and past-year ADR reporting among healthcare professionals (HCPs) in Uganda.<h4>Setting</h4>Geographically diverse health facilities (public, private for-profit, private not-for-profit).<h4>Participants</h4>Of 2000 questionnaires distributed, 1345 were completed: return rate of 67%.<h4>Primary and secondary outcome measures</h4>Per cent HCPs who suspected ADR in the past month;  ...[more]

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