Ontology highlight
ABSTRACT:
SUBMITTER: Choi SH
PROVIDER: S-EPMC4244629 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Choi Seung Hee SH Hyeon Do Young do Y Lee Ll Hwan LH Park Su Jin SJ Han Seungmin S Lee In Chul IC Hwang Daehee D Nam Hong Gil HG
Scientific reports 20141126
Many of duplicated genes are enriched in signaling pathways. Recently, gene duplication of kinases has been shown to provide genetic buffering and functional diversification in cellular signaling. Transcription factors (TFs) are also often duplicated. However, how duplication of TFs affects their regulatory structures and functions of target genes has not been explored at the systems level. Here, we examined regulatory and functional roles of duplication of three major ARR TFs (ARR1, 10, and 12) ...[more]