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Gene duplication of type-B ARR transcription factors systematically extends transcriptional regulatory structures in Arabidopsis.


ABSTRACT: Many of duplicated genes are enriched in signaling pathways. Recently, gene duplication of kinases has been shown to provide genetic buffering and functional diversification in cellular signaling. Transcription factors (TFs) are also often duplicated. However, how duplication of TFs affects their regulatory structures and functions of target genes has not been explored at the systems level. Here, we examined regulatory and functional roles of duplication of three major ARR TFs (ARR1, 10, and 12) in Arabidopsis cytokinin signaling using wild-type and single, double, and triple deletion mutants of the TFs. Comparative analysis of gene expression profiles obtained from Arabidopsis roots in wild-type and these mutants showed that duplication of ARR TFs systematically extended their transcriptional regulatory structures, leading to enhanced robustness and diversification in functions of target genes, as well as in regulation of cellular networks of target genes. Therefore, our results suggest that duplication of TFs contributes to robustness and diversification in functions of target genes by extending transcriptional regulatory structures.

SUBMITTER: Choi SH 

PROVIDER: S-EPMC4244629 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Gene duplication of type-B ARR transcription factors systematically extends transcriptional regulatory structures in Arabidopsis.

Choi Seung Hee SH   Hyeon Do Young do Y   Lee Ll Hwan LH   Park Su Jin SJ   Han Seungmin S   Lee In Chul IC   Hwang Daehee D   Nam Hong Gil HG  

Scientific reports 20141126


Many of duplicated genes are enriched in signaling pathways. Recently, gene duplication of kinases has been shown to provide genetic buffering and functional diversification in cellular signaling. Transcription factors (TFs) are also often duplicated. However, how duplication of TFs affects their regulatory structures and functions of target genes has not been explored at the systems level. Here, we examined regulatory and functional roles of duplication of three major ARR TFs (ARR1, 10, and 12)  ...[more]

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