Differential Gene Expression Landscape of Co-Existing Cervical Pre-Cancer Lesions Using RNA-seq.
Ontology highlight
ABSTRACT:
SUBMITTER: Royse KE
PROVIDER: S-EPMC4244708 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Differential Gene Expression Landscape of Co-Existing Cervical Pre-Cancer Lesions Using RNA-seq.
Royse Kathryn E KE Zhi Degui D Conner Michael G MG Clodfelder-Miller Buffie B Srinivasasainagendra Vinodh V Vaughan Laura Kelly LK Skibola Christine F CF Crossman David K DK Levy Shawn S Shrestha Sadeep S
Frontiers in oncology 20141126
Genetic changes occurring in different stages of pre-cancer lesions reflect causal events initiating and promoting the progression to cancer. Co-existing pre-cancerous lesions including low- and high-grade squamous intraepithelial lesion (LGSIL and HGSIL), and adjacent "normal" cervical epithelium from six formalin-fixed paraffin-embedded samples were selected. Tissues from these 18 samples were isolated using laser-capture microdissection, RNA was extracted and sequenced. RNA-sequencing generat ...[more]
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