Ontology highlight
ABSTRACT:
SUBMITTER: Sawyer N
PROVIDER: S-EPMC4245168 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
ACS chemical biology 20141006 11
Protein phosphorylation is a central biological mechanism for cellular adaptation to environmental changes. Dysregulation of phosphorylation signaling is implicated in a wide variety of diseases. Thus, the ability to detect and quantify protein phosphorylation is highly desirable for both diagnostic and research applications. Here we present a general strategy for detecting phosphopeptide-protein interactions in Escherichia coli. We first redesign a model tetratricopeptide repeat (TPR) protein t ...[more]