Ontology highlight
ABSTRACT:
SUBMITTER: Lee PT
PROVIDER: S-EPMC4245930 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Lee Pin-Tse PT Chao Po-Kuan PK Ou Li-Chin LC Chuang Jian-Ying JY Lin Yen-Chang YC Chen Shu-Chun SC Chang Hsiao-Fu HF Law Ping-Yee PY Loh Horace H HH Chao Yu-Sheng YS Su Tsung-Ping TP Yeh Shiu-Hwa SH
Nucleic acids research 20141031 21
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) binds to the promoter region of mu-opioid receptor (MOR) to regulate its transcriptional activity. How hnRNP K contributes to the analgesic effects of morphine, however, is largely unknown. We provide evidence that morphine increases hnRNP K protein expression via MOR activation in rat primary cortical neurons and HEK-293 cells expressing MORs, without increasing mRNA levels. Using the bicistronic reporter assay, we examined whether morphine-me ...[more]