Ontology highlight
ABSTRACT:
SUBMITTER: Bianchini E
PROVIDER: S-EPMC4246067 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Bianchini Elisa E Testoni Stefania S Gentile Arcangelo A Calì Tito T Ottolini Denis D Villa Antonello A Brini Marisa M Betto Romeo R Mascarello Francesco F Nissen Poul P Sandonà Dorianna D Sacchetto Roberta R
The Journal of biological chemistry 20141006 48
A missense mutation in ATP2A1 gene, encoding sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA1) protein, causes Chianina cattle congenital pseudomyotonia, an exercise-induced impairment of muscle relaxation. Skeletal muscles of affected cattle are characterized by a selective reduction of SERCA1 in sarcoplasmic reticulum membranes. In this study, we provide evidence that the ubiquitin proteasome system is involved in the reduced density of mutated SERCA1. The treatment with MG132, an inhibitor ...[more]