Ontology highlight
ABSTRACT:
SUBMITTER: Hinz A
PROVIDER: S-EPMC4246071 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Hinz Andreas A Jedamzick Johanna J Herbring Valentina V Fischbach Hanna H Hartmann Jessica J Parcej David D Koch Joachim J Tampé Robert R
The Journal of biological chemistry 20141015 48
Antigen presentation to cytotoxic T lymphocytes via major histocompatibility complex class I (MHC I) molecules depends on the heterodimeric transporter associated with antigen processing (TAP). For efficient antigen supply to MHC I molecules in the ER, TAP assembles a macromolecular peptide-loading complex (PLC) by recruiting tapasin. In evolution, TAP appeared together with effector cells of adaptive immunity at the transition from jawless to jawed vertebrates and diversified further within the ...[more]