Paediatric European Risperidone Studies (PERS): context, rationale, objectives, strategy, and challenges.
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ABSTRACT:
SUBMITTER: Glennon J
PROVIDER: S-EPMC4246122 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
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Paediatric European Risperidone Studies (PERS): context, rationale, objectives, strategy, and challenges.
Glennon Jeffrey J Purper-Ouakil Diane D Bakker Mireille M Zuddas Alessandro A Hoekstra Pieter P Schulze Ulrike U Castro-Fornieles Josefina J Santosh Paramala J PJ Arango Celso C Kölch Michael M Coghill David D Flamarique Itziar I Penzol Maria J MJ Wan Mandy M Murray Macey M Wong Ian C K IC Danckaerts Marina M Bonnot Olivier O Falissard Bruno B Masi Gabriele G Fegert Jörg M JM Vicari Stefano S Carucci Sara S Dittmann Ralf W RW Buitelaar Jan K JK
European child & adolescent psychiatry 20131215 12
In children and adolescents with conduct disorder (CD), pharmacotherapy is considered when non-pharmacological interventions do not improve symptoms and functional impairment. Risperidone, a second-generation antipsychotic is increasingly prescribed off-label in this indication, but its efficacy and tolerability is poorly studied in CD, especially in young people with normal intelligence. The Paediatric European Risperidone Studies (PERS) include a series of trials to assess short-term efficacy, ...[more]
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Project description: Not available
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