Ontology highlight
ABSTRACT:
SUBMITTER: Issur M
PROVIDER: S-EPMC4246218 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Issur Moheshwarnath M Götte Matthias M
Viruses 20141106 11
Direct-acting antivirals (DAAs) have significantly improved the treatment of infection with the hepatitis C virus. A promising class of novel antiviral agents targets the HCV NS5A protein. The high potency and broad genotypic coverage are favorable properties. NS5A inhibitors are currently assessed in advanced clinical trials in combination with viral polymerase inhibitors and/or viral protease inhibitors. However, the clinical use of NS5A inhibitors is also associated with new challenges. HCV v ...[more]