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Deciding whether follow-up studies have replicated findings in a preliminary large-scale omics study.

ABSTRACT: We propose a formal method to declare that findings from a primary study have been replicated in a follow-up study. Our proposal is appropriate for primary studies that involve large-scale searches for rare true positives (i.e., needles in a haystack). Our proposal assigns an r value to each finding; this is the lowest false discovery rate at which the finding can be called replicated. Examples are given and software is available.

SUBMITTER: Heller R

PROVIDER: S-EPMC4246311 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Deciding whether follow-up studies have replicated findings in a preliminary large-scale omics study.

Heller Ruth R Bogomolov Marina M Benjamini Yoav Y

Proceedings of the National Academy of Sciences of the United States of America 20141103 46

We propose a formal method to declare that findings from a primary study have been replicated in a follow-up study. Our proposal is appropriate for primary studies that involve large-scale searches for rare true positives (i.e., needles in a haystack). Our proposal assigns an r value to each finding; this is the lowest false discovery rate at which the finding can be called replicated. Examples are given and software is available. ...[more]

PMID: 25368172

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