Ontology highlight
ABSTRACT:
SUBMITTER: Rosenstein RK
PROVIDER: S-EPMC4246326 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Rosenstein Rachel K RK Bezbradica Jelena S JS Yu Shuang S Medzhitov Ruslan R
Proceedings of the National Academy of Sciences of the United States of America 20141104 46
Allergic diseases represent a significant burden in industrialized countries, but why and how the immune system responds to allergens remain largely unknown. Because many clinically significant allergens have proteolytic activity, and many helminths express proteases that are necessary for their life cycles, host mechanisms likely have evolved to detect the proteolytic activity of helminth proteases, which may be incidentally activated by protease allergens. A cysteine protease, papain, is a pro ...[more]