Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki K
PROVIDER: S-EPMC4246345 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Suzuki Kentaro K Numata Tomokazu T Suzuki Hiroko H Raga Dennis Diana DD Ipulan Lerrie Ann LA Yokoyama Chikako C Matsushita Shoko S Hamada Michito M Nakagata Naomi N Nishinakamura Ryuichi R Kume Shoen S Takahashi Satoru S Yamada Gen G
Proceedings of the National Academy of Sciences of the United States of America 20141031 46
Masculinization of external genitalia is an essential process in the formation of the male reproductive system. Prominent characteristics of this masculinization are the organ size and the sexual differentiation of the urethra. Although androgen is a pivotal inducer of the masculinization, the regulatory mechanism under the control of androgen is still unknown. Here, we address this longstanding question about how androgen induces masculinization of the embryonic external genitalia through the i ...[more]