In silico work flow for scaffold hopping in Leishmania.

ABSTRACT:

Background

Leishmaniasis,a broad spectrum of diseases caused by several sister species of protozoa belonging to family trypanosomatidae and genus leishmania , generally affects poorer sections of the populace in third world countries. With the emergence of strains resistant to traditional therapies and the high cost of second line drugs which generally have severe side effects, it becomes imperative to continue the search for alternative drugs to combat the disease. In this work, the leishmanial genomes and the human genome have been compared to identify proteins unique to the parasite and whose structures (or those of close homologues) are available in the Protein Data Bank. Subsequent to the prioritization of these proteins (based on their essentiality, virulence factor etc.), in

SUBMITTER: Waugh B 

PROVIDER: S-EPMC4247209 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature