Small-molecule SMAC mimetics as new cancer therapeutics.
Ontology highlight
ABSTRACT:
SUBMITTER: Bai L
PROVIDER: S-EPMC4247261 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Small-molecule SMAC mimetics as new cancer therapeutics.
Bai Longchuan L Smith David C DC Wang Shaomeng S
Pharmacology & therapeutics 20140516 1
Apoptosis is a tightly regulated cellular process and faulty regulation of apoptosis is a hallmark of human cancers. Targeting key apoptosis regulators with the goal to restore apoptosis in tumor cells has been pursued as a new cancer therapeutic strategy. XIAP, cIAP1, and cIAP2, members of inhibitor of apoptosis (IAP) proteins, are critical regulators of cell death and survival and are attractive targets for new cancer therapy. The SMAC/DIABLO protein is an endogenous antagonist of XIAP, cIAP1, ...[more]
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