Epigenetic regulation of persistent pain.
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ABSTRACT:
SUBMITTER: Bai G
PROVIDER: S-EPMC4247805 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Epigenetic regulation of persistent pain.
Bai Guang G Ren Ke K Dubner Ronald R
Translational research : the journal of laboratory and clinical medicine 20140529 1
Persistent or chronic pain is tightly associated with various environmental changes and linked to abnormal gene expression within cells processing nociceptive signaling. Epigenetic regulation governs gene expression in response to environmental cues. Recent animal model and clinical studies indicate that epigenetic regulation plays an important role in the development or maintenance of persistent pain and possibly the transition of acute pain to chronic pain, thus shedding light in a direction f ...[more]
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