Ontology highlight
ABSTRACT:
SUBMITTER: Saegusa T
PROVIDER: S-EPMC4247822 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Saegusa Takumi T Di Chongzhi C Chen Ying Qing YQ
Biometrics 20140529 3
The log-rank test has been widely used to test treatment effects under the Cox model for censored time-to-event outcomes, though it may lose power substantially when the model's proportional hazards assumption does not hold. In this article, we consider an extended Cox model that uses B-splines or smoothing splines to model a time-varying treatment effect and propose score test statistics for the treatment effect. Our proposed new tests combine statistical evidence from both the magnitude and th ...[more]