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A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin.

ABSTRACT: Due to the fast-acting nature of ricin, staphylococcal enterotoxin B (SEB), and Clostridium perfringens epsilon toxin (ETX), it is necessary that therapeutic interventions following a bioterrorism incident by one of these toxins occur as soon as possible after intoxication. Moreover, because the clinical manifestations of intoxication by these agents are likely to be indistinguishable from each other, especially following aerosol exposure, we have developed a cocktail of chimeric monoclonal antibodies that is capable of neutralizing all three toxins. The efficacy of this cocktail was demonstrated in mouse models of lethal dose toxin challenge.

SUBMITTER: Sully EK 

PROVIDER: S-EPMC4248019 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin.

Sully Erin K EK   Whaley Kevin K   Bohorova Natasha N   Bohorov Ognian O   Goodman Charles C   Kim Do D   Pauly Michael M   Velasco Jesus J   Holtsberg Frederick W FW   Stavale Eric E   Aman M Javad MJ   Tangudu Chandra C   Uzal Francisco A FA   Mantis Nicholas J NJ   Zeitlin Larry L  

Toxicon : official journal of the International Society on Toxinology 20140928

Due to the fast-acting nature of ricin, staphylococcal enterotoxin B (SEB), and Clostridium perfringens epsilon toxin (ETX), it is necessary that therapeutic interventions following a bioterrorism incident by one of these toxins occur as soon as possible after intoxication. Moreover, because the clinical manifestations of intoxication by these agents are likely to be indistinguishable from each other, especially following aerosol exposure, we have developed a cocktail of chimeric monoclonal anti  ...[more]

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