Ontology highlight
ABSTRACT:
SUBMITTER: Zeitels LR
PROVIDER: S-EPMC4248289 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Zeitels Lauren R LR Acharya Asha A Shi Guanglu G Chivukula Divya D Chivukula Raghu R RR Anandam Joselin L JL Abdelnaby Abier A AA Balch Glen C GC Mansour John C JC Yopp Adam C AC Richardson James A JA Mendell Joshua T JT
Genes & development 20141113 23
Down-regulation of miR-26 family members has been implicated in the pathogenesis of multiple malignancies. In some settings, including glioma, however, miR-26-mediated repression of PTEN promotes tumorigenesis. To investigate the contexts in which the tumor suppressor versus oncogenic activity of miR-26 predominates in vivo, we generated miR-26a transgenic mice. Despite measureable repression of Pten, elevated miR-26a levels were not associated with malignancy in transgenic animals. We documente ...[more]