Ontology highlight
ABSTRACT:
SUBMITTER: Baer R
PROVIDER: S-EPMC4248293 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Baer Romain R Cintas Célia C Cintas Célia C Dufresne Marlène M Cassant-Sourdy Stéphanie S Schönhuber Nina N Planque Laetitia L Lulka Hubert H Couderc Bettina B Bousquet Corinne C Garmy-Susini Barbara B Vanhaesebroeck Bart B Pyronnet Stéphane S Saur Dieter D Guillermet-Guibert Julie J
Genes & development 20141201 23
Increased PI 3-kinase (PI3K) signaling in pancreatic ductal adenocarcinoma (PDAC) correlates with poor prognosis, but the role of class I PI3K isoforms during its induction remains unclear. Using genetically engineered mice and pharmacological isoform-selective inhibitors, we found that the p110α PI3K isoform is a major signaling enzyme for PDAC development induced by a combination of genetic and nongenetic factors. Inactivation of this single isoform blocked the irreversible transition of exocr ...[more]