The Acinetobacter baumannii Omp33-36 porin is a virulence factor that induces apoptosis and modulates autophagy in human cells.
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ABSTRACT:
SUBMITTER: Rumbo C
PROVIDER: S-EPMC4249306 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
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The Acinetobacter baumannii Omp33-36 porin is a virulence factor that induces apoptosis and modulates autophagy in human cells.
Rumbo Carlos C Tomás María M Fernández Moreira Esteban E Soares Nelson Cruz NC Carvajal Micaela M Santillana Elena E Beceiro Alejandro A Romero Antonio A Bou Germán G
Infection and immunity 20140825 11
Acinetobacter baumannii is an extracellular opportunistic human pathogen that is becoming increasingly problematic in hospitals. In the present study, we demonstrate that the A. baumannii Omp 33- to 36-kDa protein (Omp33-36) is a porin that acts as a channel for the passage of water. The protein is found on the cell surface and is released along with other porins in the outer membrane vesicles (OMVs). In immune and connective cell tissue, this protein induced apoptosis by activation of caspases ...[more]
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